多页横向表格的宽度和高度问题

Question

我正在撰写论文并尝试将表格转换为 LaTeX（http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523805/table/T1/）。它相当大，所以我使用 lscape 和 longtable 库。此外，有些行有多行，所以我使用 pbox 库（https://stackoverflow.com/questions/2895780/latex-how-to-code-tables-with-multi-line-cells）。

我面临两个问题。

首先处理列 - 尽管尝试设置p宽度，但我没有看到列宽度的变化。

    \begin{longtable}{@{}p{50pt}|ll|p{40pt}@{}@{}p{100pt}|p{40pt}|c|c|c|c|c|c|p{30pt}|p{50pt}|}

当前渲染在 40pt 和 100pt 列之间有大量额外空间，并且最后的 50pt 列超出了页面范围。

我遇到的第二个问题与使用 pbox hack 的线条有关 - 使用它们的框没有与其他单元格正确对齐。

我这样做对吗？有什么想法吗？

完整代码如下：

    \documentclass[12pt]{article}
    \usepackage{longtable}
    \usepackage{multirow}
    \usepackage{lscape}
    \usepackage{pbox}

    \begin{document}
    \begin{landscape}
    \begin{center}
    \setlength{\tabcolsep}{2pt}
    \small
    \begin{longtable}{@{}p{50pt}|ll|p{40pt}@{}@{}p{100pt}|p{40pt}|c|c|c|c|c|c|p{30pt}|p{50pt}|}
    \caption{A simple longtable example}\\
    \hline
     & \textbf{ID} & \textbf{Sex} & \textbf{Age of onset (death)} & \textbf{Clinical Presentation} & \textbf{Family Hx} & \multicolumn{6}{c}{\textbf{Biochemical Features}} & \textbf{Gene Candidate(s)} \\
     & & & & & & Tissue(s) & I & II & III & IV & \pbox{30pt}{mtDNA \\ quantity} & \\
     \hline
    \endfirsthead
    \multicolumn{4}{c}%
    {\tablename\ \thetable\ -- \textit{Continued from previous page}} \\
    \hline
     & \textbf{ID} & \textbf{Sex} & \textbf{Age of onset (death)} & \textbf{Clinical Presentation} & \textbf{Family Hx} & \textbf{Tissue(s)} & \textbf{I} & \textbf{II} & \textbf{III} & \textbf{IV} & \pbox{30pt}{mtDNA \\ quantity} & \textbf{Gene Candidate(s)} \\
    \hline
    \endhead
    \hline \multicolumn{4}{r}{\textit{Continued on next page}} \\
    \endfoot
    \hline
    \endlastfoot
    Complex I & P1 & M & $<$1mo & lethal infantile mitochondrial disease &  & fib & $\downarrow\downarrow$ &  &  &  & nd & *ACAD9 \\
    & P2 & F & $<$1wk (3wk) & hypotonia, lethargy, respiratory distress, metabolic acidosis, FTT &  & fib & $\downarrow\downarrow$ &  & $\downarrow$ & $\downarrow$ & nd & *POLG \\
    & P3 & F & $<$1wk (4mo) & severe IUGR, FTT, recurrent episodes of metabolic acidosis &  & skm, fib & $\downarrow\downarrow$ &  &  &  & nd & NDUFB3 \\
    & P4 & F & in utero (in utero) & multiple pterygium syndrome, severe fetal hydrops, IUGR, terminated at 21w & cons. (1st) & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$}  &  &  &  & nd & AKR1B15 \\
    & P5 & F & $<$1wk (1yr) & lethargy, tachypnea, organomegaly, renal \& liver failure &  & skm,liv,hea & $\downarrow\downarrow$ &  &  &  & 49\% liv & - \\
    & P6 & M & $<$1wk & bilateral optic nerve hypoplasia, lethargy, FTT &  & skm,liv,fib & $\downarrow$ &  &  &  & nd & - \\
    & P7 & M & $<$6mo (28mo) & cystic leukodystrophy, FTT, severe metabolic acidosis &  & skm,liv,fib & $\downarrow\downarrow$ &  &  &  & nd & - \\
    & P8 & F & $<$3m (8yr) & leukodystrophy, DD, abnormal LFTs, vasculitic rash &  & \pbox{20cm}{skm \\ fib \\liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$ \\ $\sim$ } &  &  &  & nd & - \\
    & P9 & F & in utero (4d) & leukodystrophy, IUGR, metabolic acidosis, seizures &  & \pbox{20cm}{liv,fib \\ skm} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  &  &  & 460\% liv & - \\
    & P10 & F & $<$1yr (na) & FFT, DD, seizures, hypotonia, prominent extra-axial CSF space &  & skm & $\downarrow$ &  &  &  & nd & - \\  \hline
    Complex III & P11 & F &$<$1wk & severe global DD, tachypnea, metabolic acidosis, renal tubular acidosis, FTT &  & \pbox{20cm}{skm,liv \\ fib} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  & 47\% skm & *BCS1L \\
    & P12 & M &$<$1wk (na) & severe IUGR, lethargy, metabolic acidosis, renal tubular acidosis, dysmorphic facies & cons. (1st). & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  & nd & *TYMP, MTCH1, C6orf125 \\
    & P13 & M &$<$6mo & hypotonia, FTT, DD, short stature, rickets, pruritis, dysmorphic facies & cons. (1st) & \pbox{20cm}{skm \\ liv} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & nd & ACADSB \\
    & P14 & M &$<$1wk (na) & fetal hypokinesia, Pierre Robin sequence, intra-abdominal calcification &  & skm,fib &  &  & $\downarrow\downarrow$ &  & nd & UCP1, MTHFD1L \\
    & P15 & F & in utero (5yr) & ventriculomegaly, apnea, dev.regression, hypotonia, seizures &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\sim$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  & nd & UQCR10 \\
    & P16 & M &$<$1wk & cardiorespiratory arrest, metabolic acidosis, renal tubular acidosis &  & fib &  &  & $\downarrow\downarrow$ &  & nd & - \\ \hline
    Complex IV & P17 & M &$<$1wk & neonatal lactic acidosis, cystic leukodystrophy &  & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & *COX6B1 \\
    & P18 & M &$<$1wk & hypsarrhythmia, FTT, dystonia, squint &  & \pbox{20cm}{skm \\ fib} & $\sim$ &  & $\sim$ & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & nd & *GFM1, ACOX3 \\
    & P19 & F &$<$1mo (12mo) & DD, seizure, hypotonia, doesn’t fix \& follow, cortical atrophy & cons. (1st+1) & fib &  &  &  & $\downarrow\downarrow$ & nd & ACAD8 \\
    & P20 & F &$<$1yr & mild global DD, hypotonia, mild cerebral atrophy & sib. & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & C7orf10, MTERF \\
    & P21 & M & 1mo (7mo) & Leigh syndrome, global DD, FTT, hypotonia, seizures & cons. (2nd) & fib &  &  &  & $\downarrow\downarrow$ & nd & - \\
    & P22 & F & in utero & IUGR, oligohydramnios, severe global DD, seizures, microcephaly, hyperthermia & cons. (1st), sib. & \pbox{20cm}{skm,liv \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & - \\
    & P23 & F &$<$1mo & profound hypotonia, paucity of movement &  & skm &  &  &  & $\downarrow\downarrow$ & 37\% skm & - \\
    & P24 & M &$<$1yr & DD, hypotonia, apnea, spastic diplegia, dysmorphic &  & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 84\% skm & - \\
    & P25 & M &$<$6mo & Leigh-like syndrome, respiratory failure, lactic acidosis, RRF &  & skm &  &  &  & $\downarrow\downarrow$ & nd & - \\ \hline
    Combined OXPHOS deficiencies & P26 & M & 3wk & FTT, metabolic acidosis, hepatomegaly, apnea & cons. (1st) & \pbox{20cm}{skm \\ liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} &  & nd & LYRM4 \\
    & P27 & M &$<$1wk (2mo) & FTT, hypotonia, hypothermia, hypertrophic cardiomyopathy, hepatomegaly & cons. (1st), sib. & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 800\% liv & *TSFM \\
    & P28 & F &$<$1mo (1mo) & FTT, hypertonia, hypertrophic cardiomyopathy, respiratory arrest & cons. (1st), sib. & fib & $\downarrow$ &  & $\downarrow$ & $\downarrow$ & nd & *TSFM \\
    & P29 & F &$<$1yr & DD, seizures, hypotonia, episodic metabolic acidosis &  & liv & $\downarrow\downarrow$ &  &  & $\downarrow\downarrow$ & 167\% liv & *GFM1 \\
    & P30 & M &$<$1mo & FTT, DD, sensorineural deafness, renal failure, dysmorphic & cons. (1st), sib. & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 42\% skm & - \\
    & P31 & M &$<$1yr & hypertrophic cardiomyopathy &  & \pbox{20cm}{hea \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & C1orf31 \\
    & P32 & M &$<$6mo & gastroesophageal reflux, FFT, hypotonia, respiratory distress, lactic acidosis &  & skm & $\downarrow\downarrow$ &  & $\downarrow\downarrow$ & $\downarrow\downarrow$ & nd & EARS2 \\
    & P33 & M &$<$1yr (20mo) & FTT, dev.regression, microcephaly &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} & 290\% skm & ALDH1B1, mtDNA del. \\
    & P34 & F &$<$1wk (4mo) & FTT, cardiac arrest, hypertrophic cardiomyopathy &  & \pbox{20cm}{skm \\ fib liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl}  & 88\% skm & - \\
    & P35 & F &$<$1wk (10d) & metabolic acidosis, cardiac failure, hemorrhagic brain infarct &  & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 190\% liv & - \\
    & P36 & M &$<$1yr & sudden-onset encephalopathy with seizures after URTI &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\sim$ \\ $\sim$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 92\% skm & - \\
    & P37 & F &$<$1yr & DD, ptosis, microcephaly, GI dysmotility &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 53\% skm & - \\
    & P38 & F &$<$1yr & leukodystrophy, speech delay, dysaesthesia in hands, dev.regression &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  & \pbox{20cm}{$\sim$ \\ nl} &  \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 112\% skm & - \\
    & P39 & M &$<$2yr & Leigh syndrome, global DD, deterioration after URTI &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow$ \\ $\sim$} & nd & - \\ \hline
    mtDNA dep. & P40 & F & in utero (stillborn) & stillborn with hypotonia and multiple fractures &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & & \pbox{20cm}{$\downarrow\downarrow$ \\ nl}& \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 8\% skm & *AARS2 \\
    & P41 & F &$<$1yr (18y) & cardioskeletal myopathy, cataracts, FTT, fatigue &  & skm & $\downarrow\downarrow$ &  & $\downarrow\downarrow$ & $\downarrow\downarrow$ & 4\% skm & AGK \\
    & P42 & F &$<$1wk (4d) & marked respiratory distress, pulmonary hypertension, cataracts & cons. (1st) & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & & \pbox{20cm}{$\downarrow\downarrow$ \\ nl}& \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & \pbox{20cm}{13\% skm \\ 88\% liv} & AGK \\ \hline\hline
    \end{longtable}
    \end{center}
    \end{landscape}
    \end{document}

Answer 1

您指定的列数多于实际使用的列数，因此最后一个列未被使用。“连续”多列比它跨越的列宽，因此强制第四列过宽，我只是让它跨越另一列。最好不要放在@{}内部列之间，否则相邻列中的文本会接触。center对 longtable 没有影响，所以我删除了它。

我添加了一些颜色以便我能看到哪一列是哪一列。

我保留了这些\parbox命令，尽管您可能不需要它们。

\documentclass[12pt]{article}
    \usepackage{longtable}
    \usepackage{multirow}
    \usepackage{lscape}
    \usepackage{pbox}
\usepackage{colortbl}
    \begin{document}
    \begin{landscape}

    \setlength{\tabcolsep}{2pt}
    \small
\noindent X\dotfill X

    \begin{longtable}{@{}p{50pt}|
>{\columncolor{red}}l
l|
>{\columncolor{yellow}\raggedright}p{70pt}
>{\columncolor{blue}\raggedright}p{70pt}|
p{40pt}|c|c|
>{\columncolor{yellow}}c|
c|c|c|
>{\columncolor{red}\raggedright\arraybackslash}p{60pt}|
%%%%>{\columncolor{yellow}\raggedright\arraybackslash}p{100pt}|
}
    \caption{A simple longtable example}\\
    \hline
     & \textbf{ID} & \textbf{Sex} & \textbf{Age of onset (death)} & \textbf{Clinical Presentation} & \textbf{Family Hx} & \multicolumn{6}{c}{\textbf{Biochemical Features}} & \textbf{Gene Candidate(s)} \\
     & & & & & & Tissue(s) & I & II & III & IV & \pbox{30pt}{mtDNA \\ quantity} & \\
     \hline
    \endfirsthead
    \multicolumn{5}{c}%
    {\tablename\ \thetable\ -- \textit{Continued from previous page}} \\
    \hline
     & \textbf{ID} & \textbf{Sex} & \textbf{Age of onset (death)} & \textbf{Clinical Presentation} & \textbf{Family Hx} & \textbf{Tissue(s)} & \textbf{I} & \textbf{II} & \textbf{III} & \textbf{IV} & \pbox{30pt}{mtDNA \\ quantity} & \textbf{Gene Candidate(s)} \\
    \hline
    \endhead
    \hline \multicolumn{4}{r}{\textit{Continued on next page}} \\
    \endfoot
    \hline
    \endlastfoot
    Complex I & P1 & M & $<$1mo & lethal infantile mitochondrial disease &  & fib & $\downarrow\downarrow$ &  &  &  & nd & *ACAD9 \\
    & P2 & F & $<$1wk (3wk) & hypotonia, lethargy, respiratory distress, metabolic acidosis, FTT &  & fib & $\downarrow\downarrow$ &  & $\downarrow$ & $\downarrow$ & nd & *POLG \\
    & P3 & F & $<$1wk (4mo) & severe IUGR, FTT, recurrent episodes of metabolic acidosis &  & skm, fib & $\downarrow\downarrow$ &  &  &  & nd & NDUFB3 \\
    & P4 & F & in utero (in utero) & multiple pterygium syndrome, severe fetal hydrops, IUGR, terminated at 21w & cons. (1st) & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$}  &  &  &  & nd & AKR1B15 \\
    & P5 & F & $<$1wk (1yr) & lethargy, tachypnea, organomegaly, renal \& liver failure &  & skm,liv,hea & $\downarrow\downarrow$ &  &  &  & 49\% liv & - \\
    & P6 & M & $<$1wk & bilateral optic nerve hypoplasia, lethargy, FTT &  & skm,liv,fib & $\downarrow$ &  &  &  & nd & - \\
    & P7 & M & $<$6mo (28mo) & cystic leukodystrophy, FTT, severe metabolic acidosis &  & skm,liv,fib & $\downarrow\downarrow$ &  &  &  & nd & - \\
    & P8 & F & $<$3m (8yr) & leukodystrophy, DD, abnormal LFTs, vasculitic rash &  & \pbox{20cm}{skm \\ fib \\liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$ \\ $\sim$ } &  &  &  & nd & - \\
    & P9 & F & in utero (4d) & leukodystrophy, IUGR, metabolic acidosis, seizures &  & \pbox{20cm}{liv,fib \\ skm} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  &  &  & 460\% liv & - \\
    & P10 & F & $<$1yr (na) & FFT, DD, seizures, hypotonia, prominent extra-axial CSF space &  & skm & $\downarrow$ &  &  &  & nd & - \\  \hline
    Complex III & P11 & F &$<$1wk & severe global DD, tachypnea, metabolic acidosis, renal tubular acidosis, FTT &  & \pbox{20cm}{skm,liv \\ fib} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  & 47\% skm & *BCS1L \\
    & P12 & M &$<$1wk (na) & severe IUGR, lethargy, metabolic acidosis, renal tubular acidosis, dysmorphic facies & cons. (1st). & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  & nd & *TYMP, MTCH1, C6orf125 \\
    & P13 & M &$<$6mo & hypotonia, FTT, DD, short stature, rickets, pruritis, dysmorphic facies & cons. (1st) & \pbox{20cm}{skm \\ liv} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & nd & ACADSB \\
    & P14 & M &$<$1wk (na) & fetal hypokinesia, Pierre Robin sequence, intra-abdominal calcification &  & skm,fib &  &  & $\downarrow\downarrow$ &  & nd & UCP1, MTHFD1L \\
    & P15 & F & in utero (5yr) & ventriculomegaly, apnea, dev.regression, hypotonia, seizures &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\sim$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} &  & nd & UQCR10 \\
    & P16 & M &$<$1wk & cardiorespiratory arrest, metabolic acidosis, renal tubular acidosis &  & fib &  &  & $\downarrow\downarrow$ &  & nd & - \\ \hline
    Complex IV & P17 & M &$<$1wk & neonatal lactic acidosis, cystic leukodystrophy &  & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & *COX6B1 \\
    & P18 & M &$<$1wk & hypsarrhythmia, FTT, dystonia, squint &  & \pbox{20cm}{skm \\ fib} & $\sim$ &  & $\sim$ & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & nd & *GFM1, ACOX3 \\
    & P19 & F &$<$1mo (12mo) & DD, seizure, hypotonia, doesn’t fix \& follow, cortical atrophy & cons. (1st+1) & fib &  &  &  & $\downarrow\downarrow$ & nd & ACAD8 \\
    & P20 & F &$<$1yr & mild global DD, hypotonia, mild cerebral atrophy & sib. & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & C7orf10, MTERF \\
    & P21 & M & 1mo (7mo) & Leigh syndrome, global DD, FTT, hypotonia, seizures & cons. (2nd) & fib &  &  &  & $\downarrow\downarrow$ & nd & - \\
    & P22 & F & in utero & IUGR, oligohydramnios, severe global DD, seizures, microcephaly, hyperthermia & cons. (1st), sib. & \pbox{20cm}{skm,liv \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & - \\
    & P23 & F &$<$1mo & profound hypotonia, paucity of movement &  & skm &  &  &  & $\downarrow\downarrow$ & 37\% skm & - \\
    & P24 & M &$<$1yr & DD, hypotonia, apnea, spastic diplegia, dysmorphic &  & \pbox{20cm}{skm \\ fib} &  &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 84\% skm & - \\
    & P25 & M &$<$6mo & Leigh-like syndrome, respiratory failure, lactic acidosis, RRF &  & skm &  &  &  & $\downarrow\downarrow$ & nd & - \\ \hline
    Combined OXPHOS deficiencies & P26 & M & 3wk & FTT, metabolic acidosis, hepatomegaly, apnea & cons. (1st) & \pbox{20cm}{skm \\ liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl} &  & nd & LYRM4 \\
    & P27 & M &$<$1wk (2mo) & FTT, hypotonia, hypothermia, hypertrophic cardiomyopathy, hepatomegaly & cons. (1st), sib. & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 800\% liv & *TSFM \\
    & P28 & F &$<$1mo (1mo) & FTT, hypertonia, hypertrophic cardiomyopathy, respiratory arrest & cons. (1st), sib. & fib & $\downarrow$ &  & $\downarrow$ & $\downarrow$ & nd & *TSFM \\
    & P29 & F &$<$1yr & DD, seizures, hypotonia, episodic metabolic acidosis &  & liv & $\downarrow\downarrow$ &  &  & $\downarrow\downarrow$ & 167\% liv & *GFM1 \\
    & P30 & M &$<$1mo & FTT, DD, sensorineural deafness, renal failure, dysmorphic & cons. (1st), sib. & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 42\% skm & - \\
    & P31 & M &$<$1yr & hypertrophic cardiomyopathy &  & \pbox{20cm}{hea \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & nd & C1orf31 \\
    & P32 & M &$<$6mo & gastroesophageal reflux, FFT, hypotonia, respiratory distress, lactic acidosis &  & skm & $\downarrow\downarrow$ &  & $\downarrow\downarrow$ & $\downarrow\downarrow$ & nd & EARS2 \\
    & P33 & M &$<$1yr (20mo) & FTT, dev.regression, microcephaly &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow\downarrow$} & 290\% skm & ALDH1B1, mtDNA del. \\
    & P34 & F &$<$1wk (4mo) & FTT, cardiac arrest, hypertrophic cardiomyopathy &  & \pbox{20cm}{skm \\ fib liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$ \\ nl} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$ \\ nl}  & 88\% skm & - \\
    & P35 & F &$<$1wk (10d) & metabolic acidosis, cardiac failure, hemorrhagic brain infarct &  & \pbox{20cm}{liv \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 190\% liv & - \\
    & P36 & M &$<$1yr & sudden-onset encephalopathy with seizures after URTI &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\sim$} &  & \pbox{20cm}{$\sim$ \\ $\sim$} & \pbox{20cm}{$\downarrow\downarrow$ \\ $\downarrow$} & 92\% skm & - \\
    & P37 & F &$<$1yr & DD, ptosis, microcephaly, GI dysmotility &  & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  &  & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 53\% skm & - \\
    & P38 & F &$<$1yr & leukodystrophy, speech delay, dysaesthesia in hands, dev.regression &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} &  & \pbox{20cm}{$\sim$ \\ nl} &  \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 112\% skm & - \\
    & P39 & M &$<$2yr & Leigh syndrome, global DD, deterioration after URTI &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow$ \\ $\downarrow$} &  & \pbox{20cm}{$\downarrow$ \\ $\downarrow$} & \pbox{20cm}{$\downarrow$ \\ $\sim$} & nd & - \\ \hline
    mtDNA dep. & P40 & F & in utero (stillborn) & stillborn with hypotonia and multiple fractures &  & \pbox{20cm}{skm \\ fib} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & & \pbox{20cm}{$\downarrow\downarrow$ \\ nl}& \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & 8\% skm & *AARS2 \\
    & P41 & F &$<$1yr (18y) & cardioskeletal myopathy, cataracts, FTT, fatigue &  & skm & $\downarrow\downarrow$ &  & $\downarrow\downarrow$ & $\downarrow\downarrow$ & 4\% skm & AGK \\
    & P42 & F &$<$1wk (4d) & marked respiratory distress, pulmonary hypertension, cataracts & cons. (1st) & \pbox{20cm}{skm \\ liv} & \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & & \pbox{20cm}{$\downarrow\downarrow$ \\ nl}& \pbox{20cm}{$\downarrow\downarrow$ \\ nl} & \pbox{20cm}{13\% skm \\ 88\% liv} & AGK \\ \hline\hline
    \end{longtable}

    \end{landscape}
    \end{document}