自四周前以来，我们在访问托管在 II 7.5 上的应用程序（在生产环境中）时在 Chrome 中收到了 ERR_INVALID_HANDLE。该应用程序在其他浏览器和 QA 环境中均可运行 - 在此环境中，应用程序在 Chrome 中也能正常运行。
从 web.config 中删除 NEGOTIATE 键是一种选择，但我想知道问题为什么会发生，即使使用 NEGOTIATE 键，应用程序也始终正常工作，以及令我困惑的是什么它们在 QA 环境中运行，但不在生产环境中运行. 该问题出现在任何版本的 Chrome 中。
访问使用 Windows 身份验证的内联网网页时会出现此问题！
错误信息：
Cannot access this site
The web page in wapps ...... may be temporarily unavailable
or may have been moved permanently to a new web address.
ERR_INVALID_HANDLE
Fidler Information
IE x Chrome
IE
HTTP / 1.1 401 Unauthorized
Content-Length: 341
Content-Type: text / html; Charset = us-ascii
Server: Microsoft-IIS / 7.5
WWW-Authenticate: NTLM TlRMTVNTUAACAAAAGgAaADgAAAAFgomioSBPUb + cKvwAAAAAAAAAAMYAxgBSAAAABgGxHQAAAA9MAE8AQwBBAEwASQBaAEEAXwBDAE8AUgBQAAIAGgBMAE8AQwBBAEwASQBaAEEAXwBDAE8AUgBQAAEAHABTAFIAVgAtAEcAQwBXAEUAQgBQAFIARAAwADIABAAaAGwAbwBjAGEAbABpAHoAYQAuAGMAbwByAHAAAwA4AFMAUgBWAC0ARwBDAFcARQBCAFAAUgBEADAAMgAuAGwAbwBjAGEAbABpAHoAYQAuAGMAbwByAHAABQAaAGwAbwBjAGEAbABpAHoAYQAuAGMAbwByAHAABwAIADhZbSmLQdIBAAAAAA ==
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X-Powered-By: ASP.NET
Date: Fri, 18 Nov 2016 11:01:49 GMT
Proxy-Support: Session-Based-Authentication
Chrome
HTTP / 1.1 401 Unauthorized
Content-Length: 341
Content-Type: text / html; Charset = us-ascii
Server: Microsoft-IIS / 7.5
WWW-Authenticate: Negotiate oYGEMIGBoAMKAQGhCwYJKoZIgvcSAQICom0Ea2BpBgkqhkiG9xIBAgIDAH5aMFigAwIBBaEDAgEepBEYDzIwMTYxMTE4MTEwMTQ5WqUFAgMFa02mAwIBKakPGw1MT0NBTElaQS5DT1JQqhwwGqADAgEBoRMwERsPc3J2LWdjd2VicHJkMDMk
X-Powered-By: ARR / 3.0
X-Powered-By: ASP.NET
Date Fri, 18 Nov 2016 11:01:47 GMT
Proxy-Support: Session-Based-Authentication