您可以\textcolor
在节点内部使用:
\documentclass{article}
\usepackage{tikz}
\begin{document}
\begin{tikzpicture}
\node[fill=green, text=red, circle, draw=black] {With
\textcolor{cyan}{node}};
\draw[fill=cyan] (3,0) circle (1cm) node[text=blue] {With draw};
\end{tikzpicture}
\end{document}